Transcriptional mutagenesis: causes and involvement in tumour development

被引：92

作者：

Bregeon, Damien ^{[3
]}

Doetsch, Paul W. ^{[1
,2
]}

机构：

[1] Emory Univ, Sch Med, Dept Biochem, Winship Canc Inst, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Radiat Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

[3] Univ Paris 11, CNRS, UMR 8621, Inst Genet & Microbiol, F-91405 Orsay, France

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 03期

基金：

美国国家卫生研究院;

关键词：

T7; RNA-POLYMERASE; BASE EXCISION-REPAIR; OXIDATIVE DNA-DAMAGE; IN-VITRO REPLICATION; ESCHERICHIA-COLI RNA; SINGLE-STRAND BREAKS; MAMMALIAN-CELLS; TRANSLESION SYNTHESIS; TEMPLATE STRAND; THYMINE GLYCOL;

D O I：

10.1038/nrc3006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The majority of human cells do not multiply continuously but are quiescent or slow-replicating and devote a large part of their energy to transcription. When DNA damage in the transcribed strand of an active gene is bypassed by a RNA polymerase, they can miscode at the damaged site and produce mutant transcripts. This process is known as transcriptional mutagenesis and, as discussed in this Perspective, could lead to the production of mutant proteins and might therefore be important in tumour development.

引用

页码：218 / U88

页数：11

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