Polyfunctionalized pyrrolidines by Ugi multicomponent reaction followed by palladium-mediated SN2′ cyclizations

被引：41

作者：

Banfi, Luca ^{[1
]}

Basso, Andrea ^{[1
]}

Cerulli, Valentina ^{[1
]}

Guanti, Giuseppe ^{[1
]}

Riva, Renata ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 04期

关键词：

D O I：

10.1021/jo702087x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R-5 = H) or a Pd(0)-mediated (RI = CO2Me) S(N)2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.

引用

页码：1608 / 1611

页数：4

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