MicroRNA dysregulation in colorectal cancer: a clinical perspective

被引：102

作者：

Dong, Y. ^{[1
,2
,3
]}

Wu, W. K. K. ^{[1
,2
]}

Wu, C. W. ^{[1
,2
]}

Sung, J. J. Y. ^{[1
,2
]}

Yu, J. ^{[1
,2
]}

Ng, S. S. M. ^{[1
,2
,3
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Inst Digest Dis, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 06期

关键词：

miRNA; colorectal cancer; diagnostic marker; prognostic marker; single-nucleotide polymorphisms; HUMAN COLON-CANCER; CIRCULATING MICRORNA; EXPRESSION PROFILES; BINDING-SITES; BIOMARKERS; ADENOCARCINOMA; CELLS; PROGNOSIS; CARCINOMA; DIAGNOSIS;

D O I：

10.1038/bjc.2011.57

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent researches have shed light on the biological importance of microRNAs (miRNAs) in colorectal cancer (CRC) genesis, progression and response to treatments. The potential utility of miRNAs in the preclinical stage have been explored and investigated. In this review, we explored the literature and reviewed the cutting edge progress in the discovery of noninvasive plasma and faecal miRNAs for CRC early diagnosis, as well as their measurability and predictability. We also discussed the utility of miRNAs as novel prognostic and predictive markers, and their association with CRC clinical phenotypes including recurrence, metastasis and therapeutic outcomes. Finally, we summarised miRNA- related single- nucleotide polymorphisms and their potential influence on sporadic CRC susceptibility and therapeutic response. In conclusion, the use of miRNAs as biomarker for CRC is still in its infancy and need further characterisation and evaluation. British Journal of Cancer (2011) 104, 893- 898. doi: 10.1038/bjc.2011.57www.bjcancer. com

引用

页码：893 / 898

页数：6

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