A novel antiprotozoal aminosteroid from Saracha punctata

被引：56

作者：

Moretti, C

Sauvain, M

Lavaud, C

Massiot, G

Bravo, JA

Muñoz, V

机构：

[1] Fac Pharm Reims, UPRESA 6013, Lab Pharmacognosie, F-51096 Reims, France

[2] ORSTOM, Inst Francais Rech Sci Dev Cooperat, F-75480 Paris 10, France

[3] IBBA, La Paz, Bolivia

[4] Univ Mayor San Andres, Inst Invest Quim, La Paz, Bolivia

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 11期

关键词：

D O I：

10.1021/np9800654

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new aminosteroid, 3 beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 mu M) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 mu M) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

引用

页码：1390 / 1393

页数：4

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[1] NMR spectroscopy of steroidal sapogenins and steroidal saponins: An update [J].