Chromatin Topology and the Regulation of Antigen Receptor Assembly

被引：73

作者：

Bossen, Claudia ^{[1
]}

Mansson, Robert ^{[1
]}

Murre, Cornelis ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Mol Biol, Div Biol Sci, La Jolla, CA 92093 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 | 2012年 / 30卷

关键词：

antigen receptor loci; chromatin structure; epigenetics; genomic interactions; B-CELL-DEVELOPMENT; HEAVY-CHAIN GENE; ANTISENSE INTERGENIC TRANSCRIPTION; COMMON LYMPHOID PROGENITOR; TCR-ALPHA LOCUS; IMMUNOGLOBULIN-HEAVY; V(D)J RECOMBINATION; HUMAN GENOME; GAMMA-DELTA; IGH LOCUS;

D O I：

10.1146/annurev-immunol-020711-075003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an organism's ontogeny and in the adult, each B and T lymphocyte generates a unique antigen receptor, thereby creating the organism's ability to respond to a vast number of different antigens. The antigen receptor loci are organized into distinct regions that contain multiple variable (V), diversity (D), and/or joining (J) and constant (C) coding elements that are scattered across large genomic regions. In this review, we discuss the epigenetic modifications that take place in the different antigen receptor loci, the chromatin structure adopted by the antigen receptor loci to allow recombination of elements separated by large genomic distances, and the relationship between epigenetics and chromatin structure and how they relate to the generation of antigen receptor diversity.

引用

页码：337 / 356

页数：20

共 145 条

[1] Noncoding transcription controls downstream promoters to regulate T-cell receptor α recombination [J].

Abarrategui, Iratxe ;

Krangel, Michael S. .

EMBO JOURNAL, 2007, 26 (20) :4380-4390

[2] Regulation of T cell receptor-α gene recombination by transcription [J].

Abarrategui, Iratxe ;

Krangel, Michael S. .

NATURE IMMUNOLOGY, 2006, 7 (10) :1109-1115

[3] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[4] Preferential ADV-AJ association during recombination in the mouse T-cell receptor alpha/delta locus [J].

Ande-Garcia, C ;

Gallagher, M ;

Marche, PN ;

Jouvin-Marche, E .

IMMUNOGENETICS, 2001, 52 (3-4) :224-230

[5] OVERUSAGE OF MOUSE DH GENE SEGMENT, DFL16.1, IS STRAIN-DEPENDENT AND DETERMINED BY CIS-ACTING ELEMENTS [J].

ATKINSON, MJ ;

CHANG, YH ;

CELLER, JW ;

HUANG, C ;

PAIGE, CJ ;

WU, GE .

DEVELOPMENTAL IMMUNOLOGY, 1994, 3 (04) :283-295

[6]

BANGS LA, 1991, J IMMUNOL, V146, P1996

[7] Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination [J].

Bates, Jamie Geier ;

Cado, Dragana ;

Nolla, Hector ;

Schlissel, Mark S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (13) :3247-3256

[8] The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules [J].

Bau, Davide ;

Sanyal, Amartya ;

Lajoie, Bryan R. ;

Capriotti, Emidio ;

Byron, Meg ;

Lawrence, Jeanne B. ;

Dekker, Job ;

Marti-Renom, Marc A. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (01) :107-+

[9] Genomic maps and comparative analysis of histone modifications in human and mouse [J].

Bernstein, BE ;

Kamal, M ;

Lindblad-Toh, K ;

Bekiranov, S ;

Bailey, DK ;

Huebert, DJ ;

McMahon, S ;

Karlsson, EK ;

Kulbokas, EJ ;

Gingeras, TR ;

Schreiber, SL ;

Lander, ES .

CELL, 2005, 120 (02) :169-181

[10] The mammalian epigenome [J].

Bernstein, Bradley E. ;

Meissner, Alexander ;

Lander, Eric S. .

CELL, 2007, 128 (04) :669-681

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