Chromatin Topology and the Regulation of Antigen Receptor Assembly

被引：73

作者：

Bossen, Claudia ^{[1
]}

Mansson, Robert ^{[1
]}

Murre, Cornelis ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Mol Biol, Div Biol Sci, La Jolla, CA 92093 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 | 2012年 / 30卷

关键词：

antigen receptor loci; chromatin structure; epigenetics; genomic interactions; B-CELL-DEVELOPMENT; HEAVY-CHAIN GENE; ANTISENSE INTERGENIC TRANSCRIPTION; COMMON LYMPHOID PROGENITOR; TCR-ALPHA LOCUS; IMMUNOGLOBULIN-HEAVY; V(D)J RECOMBINATION; HUMAN GENOME; GAMMA-DELTA; IGH LOCUS;

D O I：

10.1146/annurev-immunol-020711-075003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an organism's ontogeny and in the adult, each B and T lymphocyte generates a unique antigen receptor, thereby creating the organism's ability to respond to a vast number of different antigens. The antigen receptor loci are organized into distinct regions that contain multiple variable (V), diversity (D), and/or joining (J) and constant (C) coding elements that are scattered across large genomic regions. In this review, we discuss the epigenetic modifications that take place in the different antigen receptor loci, the chromatin structure adopted by the antigen receptor loci to allow recombination of elements separated by large genomic distances, and the relationship between epigenetics and chromatin structure and how they relate to the generation of antigen receptor diversity.

引用

页码：337 / 356

页数：20

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