Branching out to gain control:: how the pre-TCR is linked to multiple functions

被引：102

作者：

Kruisbeek, AM

Haks, MC

Carleton, M

Michie, AM

Zúñiga-Pflücker, JC

Wiest, DL

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[3] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 12期

基金：

英国医学研究理事会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-5699(00)01744-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCR beta locus, and further differentiation.

引用

收藏

页码：637 / 644

页数：8

相关论文

共 81 条

[1] Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein [J].

Aifantis, I ;

Pivniouk, VI ;

Gärtner, F ;

Feinberg, J ;

Swat, W ;

Alt, FW ;

von Boehmer, H ;

Geha, RS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (08) :1093-1102

[2] Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus [J].

Aifantis, I ;

Buer, J ;

vonBoehmer, H ;

Azogui, O .

IMMUNITY, 1997, 7 (05) :601-607

[3] On the role of the pre T cell receptor in αβ versus γδ T lineage commitment [J].

Aifantis, L ;

Azogui, O ;

Feinberg, J ;

Saint-Ruf, C ;

Buer, J ;

von Boehmer, H .

IMMUNITY, 1998, 9 (05) :649-655

[4] Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis [J].

Alberola-Ila, J ;

Levin, SD ;

Barton, G ;

Forbush, K ;

Zon, LI ;

Perlmutter, RM .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (08) :1077-1082

[5] Thymocyte selection: not by TCR alone [J].

Amsen, D ;

Kruisbeek, AM .

IMMUNOLOGICAL REVIEWS, 1998, 165 :209-229

[6]

Barndt R, 1999, J IMMUNOL, V163, P3331

[7] Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required [J].

Berger, MA ;

Dave, V ;

Rhodes, MR ;

Bosma, GC ;

Bosma, MJ ;

Kappes, DJ ;

Wiest, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) :1461-1467

[8] In thymic selection, peptide diversity gives and takes away [J].

Bevan, MJ .

IMMUNITY, 1997, 7 (02) :175-178

[9] p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes [J].

Bogue, MA ;

Zhu, CM ;

AguilarCordova, E ;

Donehower, LA ;

Roth, DB .

GENES & DEVELOPMENT, 1996, 10 (05) :553-565

[10] CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4(+)CD8(+) thymocytes, and in B cell maturation [J].

Byth, KF ;

Conroy, LA ;

Howlett, S ;

Smith, AJH ;

May, J ;

Alexander, DR ;

Holmes, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1707-1718

← 1 2 3 4 5 6 7 8 9 →