Structural and morphological investigation of magnetic nanoparticles based on iron oxides for biomedical applications

被引：38

作者：

Haddad, Paula S. ^{[1
]}

Martins, Tatiana M. ^{[1
,2
]}

D'Souza-Li, Lilia ^{[3
]}

Li, Li M. ^{[4
]}

Metze, Konradin ^{[5
]}

Adam, Randall L. ^{[5
]}

Knobel, Marcelo ^{[2
]}

Zanchet, Daniela ^{[1
]}

机构：

[1] Lab Nacl Luz Sincrotron LNLS, BR-13083970 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13083970 Campinas, SP, Brazil

[3] Univ Estadual Campinas, Fac Ciencias Med, Lab Endocrinol Pediat, BR-13083970 Campinas, SP, Brazil

[4] Univ Estadual Campinas, Fac Ciencias Med, Dept Neurol, BR-13083970 Campinas, SP, Brazil

[5] Univ Estadual Campinas, Fac Ciencias Med, Dept Anat Patol, Grp Interdisciplinar Patol Analit Celular, BR-13083970 Campinas, SP, Brazil

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2008年 / 28卷 / 04期

关键词：

magnetite; DMSA; nanoparticles; MRI; SAXS; biomedical applications;

D O I：

10.1016/j.msec.2007.04.014

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The present work reports the synthesis, characterization and properties of magnetic iron oxide nanoparticles for biomedical applications, correlating the nanoscale tunabilities in terms of size, structure, and magnetism. Magnetic nanoparticles in different conditions were prepared through thermal decomposition of Fe(acac)3 in the presence of 1,2 hexadecanodiol (reducing agent) and oleic acid and oleylamine (ligands) in a hot organic solvent. The 2,3-dimercaptosuccinic acid (DMSA) was exchanged onto the nanocrystal surface making the particles stable in water. Nanoparticles were characterized by X-ray diffraction (XRD) measurements, small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). Preliminary tests of incorporation of these nanoparticles in cells and their magnetic resonance image (MRI) were also carried out. The magnetization characterizations were made by isothermal magnetic measurements. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：489 / 494

页数：6

共 26 条

[11] The small-angle X-ray scattering beamline of the Brazilian Synchrotron Light Laboratory [J].

Kellermann, G ;

Vicentin, F ;

Tamura, E ;

Rocha, M ;

Tolentino, H ;

Barbosa, A ;

Craievich, A ;

Torriani, I .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1997, 30 (02) :880-883

[12]

Klug H.P., 1974, XRAY DIFFRACTION PRO, Vsecond, P992

[13] Magnetic resonance molecular imaging with nanoparticles [J].

Lanza, GM ;

Winter, PM ;

Caruthers, SD ;

Morawski, AM ;

Schmieder, AH ;

Crowder, KC ;

Wickline, SA .

JOURNAL OF NUCLEAR CARDIOLOGY, 2004, 11 (06) :733-743

[14] ATYPICAL STROMAL GIANT-CELLS OF CERVIX UTERI - EVIDENCE OF SCHWANN-CELL ORIGIN [J].

METZE, K ;

ANDRADE, LALD .

PATHOLOGY RESEARCH AND PRACTICE, 1991, 187 (08) :1031-1035

[15] Magnetic nanoparticle design for medical diagnosis and therapy [J].

Mornet, S ;

Vasseur, S ;

Grasset, F ;

Duguet, E .

JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (14) :2161-2175

[16] Synthesis and characterization of monodisperse nanocrystals and close-packed nanocrystal assemblies [J].

Murray, CB ;

Kagan, CR ;

Bawendi, MG .

ANNUAL REVIEW OF MATERIALS SCIENCE, 2000, 30 :545-610

[17] Monodisperse nanoparticles of Ni and NiO: Synthesis, characterization, self-assembled superlattices, and catalytic applications in the Suzuki coupling reaction [J].

Park, J ;

Kang, E ;

Son, SU ;

Park, HM ;

Lee, MK ;

Kim, J ;

Kim, KW ;

Noh, HJ ;

Park, JH ;

Bae, CJ ;

Park, JG ;

Hyeon, T .

ADVANCED MATERIALS, 2005, 17 (04) :429-+

[18] Anti-cancer drug diffusion within living rat brain tissue:: an experimental study using [3H](6)-5-fluorouracil-loaded PLGA microspheres [J].

Roullin, VG ;

Deverre, JR ;

Lemaire, L ;

Hindré, F ;

Venier-Julienne, MC ;

Vienet, R ;

Benoit, JP .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2002, 53 (03) :293-299

[19]

SHINKAI M, 1999, J MAGN MAGN MATER, V194, P44

[20] Succimer and the reduction of tissue lead in juvenile monkeys [J].

Smith, DR ;

Woolard, D ;

Luck, ML ;

Laughlin, NK .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2000, 166 (03) :230-240

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