Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cells

被引：582

作者：

Xie, Jin ^{[1
]}

Xu, Chenjie ^{[1
]}

Kohler, Nathan ^{[1
]}

Hou, Yanglong ^{[1
]}

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701975

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dopamine-PEG based ligand is synthesized and used to stabilize monodisperse 9 nm Fe3O4 nanoparticles in physiological conditions and against non-specific uptake by macrophage cells. Such stable nanoparticles can be used to enhance the efficiency in target-specific drug delivery and to increase the signal-to-noise ratio in magnetic resonance imaging (MRI).

引用

页码：3163 / +

页数：5

共 18 条

[1] Comparative study of ferrofluids based on dextran-coated iron oxide and metal nanoparticles for contrast agents in magnetic resonance imaging
Bautista, MC
Bomati-Miguel, O
Zhao, X
Morales, MP
González-Carreño, T
de Alejo, RP
Ruiz-Cabello, J
Veintemillas-Verdaguer, S
[J]. NANOTECHNOLOGY, 2004, 15 (04) : S154 - S159
[2] Functionalisation of magnetic nanoparticles for applications in biomedicine
Berry, CC
Curtis, ASG
[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) : R198 - R206
[3] Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging
Jun, YW
Huh, YM
Choi, JS
Lee, JH
Song, HT
Kim, S
Yoon, S
Kim, KS
Shin, JS
Suh, JS
Cheon, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) : 5732 - 5733
[4] Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain
Kim, DK
Zhang, Y
Kehr, J
Klason, T
Bjelke, B
Muhammed, M
[J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) : 256 - 261
[5] Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery
Kohler, N
Sun, C
Fichtenholtz, A
Gunn, J
Fang, C
Zhang, MQ
[J]. SMALL, 2006, 2 (06) : 785 - 792
[6] Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice
Lacava, LM
Lacava, ZGM
Da Silva, MF
Silva, O
Chaves, SB
Azevedo, RB
Pelegrini, F
Gansau, C
Buske, N
Sabolovic, D
Morais, PC
[J]. BIOPHYSICAL JOURNAL, 2001, 80 (05) : 2483 - 2486
[7] Moghimi SM, 2001, PHARMACOL REV, V53, P283
[8] Magnetic nanoparticle design for medical diagnosis and therapy
Mornet, S
Vasseur, S
Grasset, F
Duguet, E
[J]. JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (14) : 2161 - 2175
[9] Interactions between a macrophage cell line (J774A1) and surface-modified poly(D,L-lactide) nanocapsules bearing poly(ethylene glycol)
Mosqueira, VCF
Legrand, P
Gref, R
Heurtault, B
Appel, M
Barratt, G
[J]. JOURNAL OF DRUG TARGETING, 1999, 7 (01) : 65 - 78
[10] Applications of magnetic nanoparticles in biomedicine
Pankhurst, QA
Connolly, J
Jones, SK
Dobson, J
[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) : R167 - R181

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