Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cells

被引：582

作者：

Xie, Jin ^{[1
]}

Xu, Chenjie ^{[1
]}

Kohler, Nathan ^{[1
]}

Hou, Yanglong ^{[1
]}

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701975

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dopamine-PEG based ligand is synthesized and used to stabilize monodisperse 9 nm Fe3O4 nanoparticles in physiological conditions and against non-specific uptake by macrophage cells. Such stable nanoparticles can be used to enhance the efficiency in target-specific drug delivery and to increase the signal-to-noise ratio in magnetic resonance imaging (MRI).

引用

收藏

页码：3163 / +

页数：5

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