Autoimmunity in Chagas heart disease

被引：61

作者：

Leon, JS

Engman, DM ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Ctr, Dept Pathol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Ctr, Dept Microbiol Immunol, Chicago, IL 60611 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 5-6期

关键词：

myocarditis; Chagas heart disease myosin; autoimmunity;

D O I：

10.1016/S0020-7519(01)00163-1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The possibility that cardiac autoimmunity contributes to the pathogenesis of Chagas heart disease is controversial. Ln this paper, we address the following questions regarding the genesis of autoimmunity in Chagas heart disease: (i) What mechanism(s) are potentially responsible for the generation of self-directed antibodies End lymphocytes? () What is the evidence that any of these mechanisms actually can occur? (iii) What are the implications of the presence of autoimmunity for other mechanisms of cardiac inflammation? (C) 2001 Published by Elsevier Science Ltd. on behalf of Australian Society for Parasitology Inc.

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页码：555 / 561

页数：7

相关论文

共 24 条

[1] AUTOIMMUNE MYOCARDITIS INDUCED BY TRYPANOSOMA-CRUZI [J].

ACOSTA, AM ;

SANTOSBUCH, CA .

CIRCULATION, 1985, 71 (06) :1255-1261

[2] Autoimmunity in Chagas' disease - Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient [J].

CunhaNeto, E ;

Coelho, V ;

Guilherme, L ;

Fiorelli, A ;

Stolf, N ;

Kalil, J .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (08) :1709-1712

[3] AUTOIMMUNITY IN CHAGAS-DISEASE CARDIOPATHY - BIOLOGICAL RELEVANCE OF A CARDIAC MYOSIN-SPECIFIC EPITOPE CROSS-REACTIVE TO AN IMMUNODOMINANT TRYPANOSOMA-CRUZI ANTIGEN [J].

CUNHANETO, E ;

DURANTI, M ;

GRUBER, A ;

ZINGALES, B ;

DEMESSIAS, I ;

STOLF, N ;

BELLOTTI, G ;

PATARROYO, ME ;

PILLEGGI, F ;

KALIL, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3541-3545

[4] ANTI-MYOSIN HUMORAL IMMUNE-RESPONSE FOLLOWING CARDIAC INJURY [J].

DESCHEERDER, IK ;

DEBUYZERE, ML ;

DELANGHE, JR ;

CLEMENT, DL ;

WIEME, RJ .

AUTOIMMUNITY, 1989, 4 (1-2) :51-58

[5] Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity [J].

Dighiero, G ;

Rose, NR .

IMMUNOLOGY TODAY, 1999, 20 (09) :423-428

[6]

Fedoseyeva EV, 1999, J IMMUNOL, V162, P6836

[7]

GRAUERT MR, 1993, CLIN EXP IMMUNOL, V93, P85, DOI 10.1111/j.1365-2249.1993.tb06501.x

[8] Mapping autoimmunity genes [J].

Griffiths, MM ;

Encinas, JA ;

Remmers, EF ;

Kuchroo, VK ;

Wilder, RL .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (06) :689-700

[9] Chagas' disease and the autoimmunity hypothesis [J].

Kierszenbaum, F .

CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (02) :210-+

[10] ANTIHEART ANTIBODY-DEPENDENT CYTO-TOXICITY IN THE SERA OF MICE CHRONICALLY INFECTED WITH TRYPANOSOMA-CRUZI [J].

LAGUENS, RP ;

MECKERT, PC ;

CHAMBO, JG .

INFECTION AND IMMUNITY, 1988, 56 (04) :993-997