Opinion - Proteomic analysis of cancer-cell mitochondria

被引：78

作者：

Verma, M

Kagan, J

Sidransky, D

Srivastava, S ^{[1
]}

机构：

[1] NCI, Div Canc Prevent, Canc Biomarkers Res Grp, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 10期

关键词：

D O I：

10.1038/nrc1192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitochondrial dysfunction and mutations in mitochondrial DNA have been frequently reported in cancer cells. Mitochondrial gene-expression signatures of transformed cells have been identified; however, the phenotypic effects of these genetic alterations remain to be established. Identification of mitochondrial proteins that are aberrantly expressed in cancer cells has been made possible by the recent development of mitochonddal functional proteomics and could identify new markers for early detection and risk assessment, as well as targets for therapeutic intervention.

引用

页码：789 / 795

页数：8

共 45 条

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