Germinal centres and B cell lymphomagenesis

被引：358

作者：

Basso, Katia ^{[1
,2
]}

Dalla-Favera, Riccardo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[3] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

[4] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA

[5] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 03期

关键词：

NF-KAPPA-B; SECRETING PLASMA-CELLS; DEREGULATED BCL6 EXPRESSION; CLASS-SWITCH RECOMBINATION; NON-HODGKIN-LYMPHOMA; C-MYC; TRANSCRIPTION FACTOR; FOLLICULAR LYMPHOMA; CHROMOSOMAL TRANSLOCATIONS; BURKITT-LYMPHOMA;

D O I：

10.1038/nri3814

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity antibodies and are also the origin of most human B cell lymphomas. Recent progress has been made in identifying the functionally relevant stages of the GC and the complex trafficking mechanisms of B cells within the GC. These studies have identified transcription factors and signalling pathways that regulate distinct phases of GC development. Notably, these factors and pathways are hijacked during tumorigenesis, as revealed by analyses of the genetic lesions associated with various types of B cell lymphomas. This Review focuses on recent insights into the mechanisms that regulate GC development and that are relevant for human B cell lymphomagenesis.

引用

页码：172 / 184

页数：13

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