Germinal centres and B cell lymphomagenesis

被引：358

作者：

Basso, Katia ^{[1
,2
]}

Dalla-Favera, Riccardo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[3] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

[4] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA

[5] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 03期

关键词：

NF-KAPPA-B; SECRETING PLASMA-CELLS; DEREGULATED BCL6 EXPRESSION; CLASS-SWITCH RECOMBINATION; NON-HODGKIN-LYMPHOMA; C-MYC; TRANSCRIPTION FACTOR; FOLLICULAR LYMPHOMA; CHROMOSOMAL TRANSLOCATIONS; BURKITT-LYMPHOMA;

D O I：

10.1038/nri3814

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity antibodies and are also the origin of most human B cell lymphomas. Recent progress has been made in identifying the functionally relevant stages of the GC and the complex trafficking mechanisms of B cells within the GC. These studies have identified transcription factors and signalling pathways that regulate distinct phases of GC development. Notably, these factors and pathways are hijacked during tumorigenesis, as revealed by analyses of the genetic lesions associated with various types of B cell lymphomas. This Review focuses on recent insights into the mechanisms that regulate GC development and that are relevant for human B cell lymphomagenesis.

引用

页码：172 / 184

页数：13

共 157 条

[51] Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis [J].

Hatzi, Katerina ;

Melnick, Ari .

TRENDS IN MOLECULAR MEDICINE, 2014, 20 (06) :343-352

[52] A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters [J].

Hatzi, Katerina ;

Jiang, Yanwen ;

Huang, Chuanxin ;

Garrett-Bakelman, Francine ;

Gearhart, Micah D. ;

Giannopoulou, Eugenia G. ;

Zumbo, Paul ;

Kirouac, Kevin ;

Bhaskara, Srividya ;

Polo, Jose M. ;

Kormaksson, Matthias ;

MacKerell, Alexander D., Jr. ;

Xue, Fengtian ;

Mason, Christopher E. ;

Hiebert, Scott W. ;

Prive, Gilbert G. ;

Cerchietti, Leandro ;

Bardwell, Vivian J. ;

Elemento, Olivier ;

Melnick, Ari .

CELL REPORTS, 2013, 4 (03) :578-588

[53] Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits [J].

Heise, Nicole ;

De Silva, Nilushi S. ;

Silva, Kathryn ;

Carette, Amanda ;

Simonetti, Giorgia ;

Pasparakis, Manolis ;

Klein, Ulf .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (10) :2103-2118

[54] The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia [J].

Hoellenriegel, Julia ;

Meadows, Sarah A. ;

Sivina, Mariela ;

Wierda, William G. ;

Kantarjian, Hagop ;

Keating, Michael J. ;

Giese, Neill ;

O'Brien, Susan ;

Yu, Albert ;

Miller, Langdon L. ;

Lannutti, Brian J. ;

Burger, Jan A. .

BLOOD, 2011, 118 (13) :3603-3612

[55] XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells [J].

Hu, Chih-Chi Andrew ;

Dougan, Stephanie K. ;

McGehee, Annette M. ;

Love, J. Christopher ;

Ploegh, Hidde L. .

EMBO JOURNAL, 2009, 28 (11) :1624-1636

[56] The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers [J].

Huang, Chuanxin ;

Gonzalez, David G. ;

Cote, Christine M. ;

Jiang, Yanwen ;

Hatzi, Katerina ;

Teater, Matt ;

Dai, Kezhi ;

Hla, Timothy ;

Haberman, Ann M. ;

Melnick, Ari .

CELL REPORTS, 2014, 8 (05) :1497-1508

[57] Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms [J].

Huang, Chuanxin ;

Hatzi, Katerina ;

Melnick, Ari .

NATURE IMMUNOLOGY, 2013, 14 (04) :380-388

[58] Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma [J].

Iqbal, J. ;

Greiner, T. C. ;

Patel, K. ;

Dave, B. J. ;

Smith, L. ;

Ji, J. ;

Wright, G. ;

Sanger, W. G. ;

Pickering, D. L. ;

Jain, S. ;

Horsman, D. E. ;

Shen, Y. ;

Fu, K. ;

Weisenburger, D. D. ;

Hans, C. P. ;

Campo, E. ;

Gascoyne, R. D. ;

Rosenwald, A. ;

Jaffe, E. S. ;

Delabie, J. ;

Rimsza, L. ;

Ott, G. ;

Mueller-Hermelink, H. K. ;

Connors, J. M. ;

Vose, J. M. ;

McKeithan, T. ;

Staudt, L. M. ;

Chan, W. C. .

LEUKEMIA, 2007, 21 (11) :2332-2343

[59] INTRACLONAL GENERATION OF ANTIBODY MUTANTS IN GERMINAL-CENTERS [J].

JACOB, J ;

KELSOE, G ;

RAJEWSKY, K ;

WEISS, U .

NATURE, 1991, 354 (6352) :389-392

[60]

Jamroziak K., 2015, LEUKEMIA LYMPHOMA, V21, P1

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