N-acylethanolamines and precursor phospholipids -: relation to cell injury

被引：195

作者：

Hansen, HS ^{[1
]}

Moesgaard, B ^{[1
]}

Hansen, HH ^{[1
]}

Petersen, G ^{[1
]}

机构：

[1] Royal Danish Sch Pharm, Dept Pharmacol, DK-2100 Copenhagen, Denmark

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2000年 / 108卷 / 1-2期

关键词：

N-acylethanolamine; N-acylethanolamine phospholipid; anandamide; N-acylethanolamine phospholipid-hydrolyzing; phospholipase D; N-acyltransferase; injury;

D O I：

10.1016/S0009-3084(00)00192-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review focuses on the relationship between formation of N-acylethanolamine phospholipids (NAPEs) and N-acylethanolamines (NAEs) catalyzed by N-acyltransferase and NAPE-hydrolyzing phospholipase D, respectively, and cell injury in tissues like brain, heart, and testis. A number of mechanisms are proposed by which these two groups of lipids may have cytoprotective properties. The mechanisms may involve activation of cannabinoid receptors, as well as non-receptor-mediated effects such as stabilization of membrane bilayers, antioxidant mechanisms, inhibition of calcium leakage from mitochondria, and direct inhibition of ceramidase. Anandamide (20:4-NAE) is formed as a minor component along with other NAEs during cell injury. Whether 20:4-NAE has a separate physiological role is at present not known, but some data suggest that 20:4-NAE may be formed, e.g. in the uterus, by a more selective mechanism without being accompanied by a vast majority of saturated and monounsaturated NAEs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 150

页数：16

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