Enantioselective Michael addition to α,β-unsaturated imides catalyzed by a bifunctional organocatalyst

被引：267

作者：

Hoashi, Y ^{[1
]}

Okino, T ^{[1
]}

Takemoto, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 26期

关键词：

imides; Michael addition; nitriles; organocatalysis; thiourea;

D O I：

10.1002/anie.200500459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) High enantioselectivities (up to 94 % ee) were attained in the Michael addition of a variety of α,β-unsaturated imides 1 and malononitrile (2) catalyzed by bifunctional thiourea 4. The pyrrolidinone moiety of 1 plays a key role in the reaction. The reaction provides access to a variety of Michael adducts 3 (see scheme; R = aryl and alkyl groups). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4032 / 4035

页数：4

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