Genetic history of an archaic hominin group from Denisova Cave in Siberia

被引：1102

作者：

Reich, David ^{[1
,2
,3
]}

Green, Richard E. ^{[4
,5
]}

Kircher, Martin ^{[4
]}

Krause, Johannes ^{[4
,6
]}

Patterson, Nick ^{[2
,3
]}

Durand, Eric Y. ^{[7
]}

Viola, Bence ^{[4
,8
]}

Briggs, Adrian W. ^{[1
,4
]}

Stenzel, Udo ^{[4
]}

Johnson, Philip L. F. ^{[9
]}

Maricic, Tomislav ^{[4
]}

Good, Jeffrey M. ^{[10
]}

Marques-Bonet, Tomas ^{[11
,12
]}

Alkan, Can ^{[11
]}

Fu, Qiaomei ^{[4
,13
]}

Mallick, Swapan ^{[1
,2
,3
]}

Li, Heng ^{[2
,3
]}

Meyer, Matthias ^{[4
]}

Eichler, Evan E. ^{[11
]}

Stoneking, Mark ^{[4
]}

Richards, Michael ^{[8
,14
]}

Talamo, Sahra ^{[8
]}

Shunkov, Michael V. ^{[15
]}

Derevianko, Anatoli P. ^{[15
]}

Hublin, Jean-Jacques ^{[8
]}

Kelso, Janet ^{[4
]}

Slatkin, Montgomery ^{[7
]}

Paeaebo, Svante ^{[4
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] MIT, Broad Inst, Cambridge, MA 02142 USA

[3] Harvard Univ, Cambridge, MA 02142 USA

[4] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany

[5] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA

[6] Univ Tubingen, Inst Nat Wissensch Archaol, D-72070 Tubingen, Germany

[7] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[8] Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany

[9] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

[10] Univ Montana, Div Biol Sci, Missoula, MT 59812 USA

[11] Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA

[12] Inst Evolutionary Biol UPF CSIC, Barcelona 08003, Spain

[13] Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, CAS MPS Joint Lab Human Evolut & Archeometry, Beijing 100044, Peoples R China

[14] Univ British Columbia, Dept Anthropol, Vancouver, BC V6T 1Z1, Canada

[15] Russian Acad Sci, Inst Archaeol Ethnog, Siberian Branch, Palaeolith Dept, Novosibirsk 630090, Russia

来源：

NATURE | 2010年 / 468卷 / 7327期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

MITOCHONDRIAL-DNA; GENOME SEQUENCE; NEANDERTHAL; PATTERNS; FLORES; SIMA;

D O I：

10.1038/nature09710

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4-6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

引用

页码：1053 / 1060

页数：8

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