Chemoselective one-pot reductive deamination of aryl amines

被引：25

作者：

Geoffroy, OJ

Morinelli, TA

Meier, GP ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Cell & Mol Pharmacol & Expt Therapeut, Charleston, SC 29425 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(01)01027-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot deamination of a wide variety of substituted anilines is described. The process involves a diazotization-dediazotization utilizing acetic acid, sodium nitrite, and sodium bisulfite- inexpensive, 'green reagents. The process occurs quickly under mild conditions, tolerates sensitive functionality, and gives products in modest-to-good yields (16-88%). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5367 / 5369

页数：3

共 24 条

[1] HYPOPHOSPHOROUS ACID AND ITS SALTS - NEW REAGENTS FOR RADICAL CHAIN DEOXYGENATION, DEHALOGENATION AND DEAMINATION [J].