The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators

被引：89

作者：

Fuller-Pace, Frances V. ^{[1
]}

Ali, Simak ^{[2
]}

机构：

[1] Univ Dundee, Ninewells Med Sch, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, SORA Div Surg Oncol Reprod Biol & Anaesthet, Dept Oncol, London W12 0NN, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

co-activator; DEAD box; p6S; p72; RNA helicase; transcriptional regulation;

D O I：

10.1042/BST0360609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DEAD box [a motif named after its amino acid sequence (Asp-Glu-Ala-Asp)] RNA helicases are known to play key roles in all cellular processes that require modulation of RNA structure. However, in recent years, several of these proteins have been found to function in transcriptional regulation. In the present paper, we shall review the literature demonstrating the action of p68 and, where data are available, p72 as transcriptional co-regulators for a range of transcription factors, namely ER alpha (oestrogen receptor alpha), the tumour suppressor p53, the myogenic regulator MyoD and Runx2, a transcription factor essential for osteoblast development. We shall also discuss evidence indicating that, in some cases at least, p68 and p72 have distinct, nonredundant, roles.

引用

页码：609 / 612

页数：4

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