Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints

被引：4

作者：

Tóth, GK

Kele, Z

Fülöp, F

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

[2] Univ Szeged, Dept Med Chem, H-6701 Szeged, Hungary

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 51期

关键词：

solid-phase chemistry; peptide analogues; combinatorial chemistry;

D O I：

10.1016/S0040-4039(00)01795-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple solid-phase method has been developed, in which Pictet-Spengler cyclization is applied on resin for the synthesis of some conformationally constrained tripeptides. This methodology was also used for the synthesis of oxytocin antagonist analogues. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：10095 / 10098

页数：4

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