Synthesis and inhibitory activity of novel tri- and tetracyclic quinolines against topoisomerases

被引：55

作者：

Sui, ZH ^{[1
]}

Altom, J ^{[1
]}

Nguyen, V ^{[1
]}

Fernandez, J ^{[1
]}

Bernstein, JI ^{[1
]}

Hiliard, JJ ^{[1
]}

Barrett, JF ^{[1
]}

Podlogar, BL ^{[1
]}

Ohemeng, KA ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 06期

关键词：

DNA-gyrase; topoisomerase II; isoindolo[2,1-a]-quinolines; pyrrolo[l; 2-a]quinolines;

D O I：

10.1016/S0968-0896(98)00030-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：735 / 742

页数：8

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