Selective amination of polyhalopyridines catalyzed by a palladium-xantphos complex

被引：72

作者：

Ji, JG ^{[1
]}

Li, T ^{[1
]}

Bunnelle, WH ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev Dept, Abbott Pk, IL 60064 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 24期

关键词：

D O I：

10.1021/ol0357696

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4a = 97:3). Amination of 2,5-dibromopyridine (11) under the same conditions exclusively affords 2-amino-5-bromopyridine 4a.

引用

页码：4611 / 4614

页数：4

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