Excitatory effects of GABA in established brain networks

被引:98
作者
Marty, A [1 ]
Llano, I [1 ]
机构
[1] Univ Paris 05, Lab Physiol Cerebrale, F-75006 Paris, France
关键词
D O I
10.1016/j.tins.2005.04.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although GABA remains the predominant inhibitory neurotransmitter of the brain, there are numerous recent examples of excitatory actions of GABA. These actions can be classified in two broad categories: phasic excitatory effects, as follow single activation of GABAergic afferents, and sustained excitatory effects, as follow prolonged activation of GABA(A) receptors. Evidence reviewed here indicates that, contrary to common belief, these effects are not restricted to embryonic or neonatal preparations.
引用
收藏
页码:284 / 289
页数:6
相关论文
共 31 条
[11]   Excitatory actions of GABA in the cortex [J].
Gulledge, AT ;
Stuart, GJ .
NEURON, 2003, 37 (02) :299-309
[12]   Developmental and circadian changes in Ca2+ mobilization mediated by GABAA and NMDA receptors in the suprachiasmatic nucleus [J].
Ikeda, M ;
Yoshioka, T ;
Allen, CN .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (01) :58-70
[13]   Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons [J].
Isomura, Y ;
Sugimoto, M ;
Fujiwara-Tsukamoto, Y ;
Yamamoto-Muraki, S ;
Yamada, J ;
Fukuda, A .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (04) :2752-2756
[14]   POSTSYNAPTIC FALL IN INTRACELLULAR PH INDUCED BY GABA-ACTIVATED BICARBONATE CONDUCTANCE [J].
KAILA, K ;
VOIPIO, J .
NATURE, 1987, 330 (6144) :163-165
[15]   Use-dependent shift from inhibitory to excitatory GABAA receptor action in SP-O interneurons in the rat hippocampal CA3 area [J].
Lamsa, K ;
Taira, T .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (03) :1983-1995
[16]   Mixed excitatory and inhibitory GABA-mediated transmission in chick cochlear nucleus [J].
Lu, T ;
Trussell, LO .
JOURNAL OF PHYSIOLOGY-LONDON, 2001, 535 (01) :125-131
[17]   Cell-type-specific GABA responses and chloride homeostasis in the cortex and amygdala [J].
Martina, M ;
Royer, S ;
Paré, D .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 86 (06) :2887-2895
[18]  
Nguyen L, 2003, J NEUROSCI, V23, P3278
[19]   Is there more to GABA than synaptic inhibition? [J].
Owens, DF ;
Kriegstein, AR .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (09) :715-727
[20]   Two developmental switches in GABAergic signalling:: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII [J].
Rivera, C ;
Voipio, J ;
Kaila, K .
JOURNAL OF PHYSIOLOGY-LONDON, 2005, 562 (01) :27-36