Quantitative 3D Analysis of Nitric Oxide Diffusion in a 3D Artery Model Using Sensor Particles

被引：29

作者：

Matsusaki, Michya ^{[1
,2
]}

Amemori, Suzuka ^{[1
]}

Kadowaki, Koji ^{[1
]}

Akashi, Mitsuru ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Tokyo, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期

关键词：

biosensors; cell adhesion; layered compounds; nitrogen oxides; thin films; FLUORESCENT INDICATORS; IN-SITU;

D O I：

10.1002/anie.201008204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NO blood lost: Three-dimensional analysis of nitric oxide (NO) diffusion in a blood vessel in response to drug stimulation was achieved by using 3D artery models including NO sensor particles (see picture). The quantity and diffusion distance of NO in the five-layered models were almost the same as those for the in vivo blood vessel response. This method enables an in vitro bioassay of tissue responses instead of animal experiments. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7557 / 7561

页数：5

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