Copper-Catalyzed Aerobic Oxidative Trifluoromethylation of H-Phosphonates Using Trimethyl(trifluoromethyl)silane

被引：13

作者：

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 10期

基金：

中国国家自然科学基金;

关键词：

copper catalysis; phosphonates; trifluoromethylation; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; MULTISUBSTRATE ANALOG INHIBITORS; MEDIATED TRIFLUOROMETHYLATION; DIFLUOROMETHYLENEPHOSPHONATE ANALOG; REDUCTIVE ELIMINATION; FACILE SYNTHESIS; BOND FORMATION; ARYL IODIDES; ARENES; FLUORINATION;

D O I：

10.1055/s-0031-1290806

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed aerobic oxidative trifluoromethylation of readily accessible H-phosphonates was demonstrated for the first time. This method not only provides an alternative method for the facile synthesis of a series of biologically important CF3-phosphonates, but also demonstrates the first example of the efficient construction of a P-CF3 bond via transition-metal catalysis.

引用

页码：1521 / 1525

页数：5

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