Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives

被引：106

作者：

Aufort, Marie

Herscovici, Jean

Bouhours, Pascale

Moreau, Nicole

Girard, Christian ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, Chim Mol Paris Ctr, INSERM, CNRS,UMR 8151,U640,Unite Pharmacol Chim & Genet, F-75005 Paris, France

[2] Ecole Natl Super Chim Paris, Chim Mol Paris Ctr, CNRS, IFR 2769,UMR 7573,Lab Synthese Organ Select & Pro, F-75005 Paris, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 03期

关键词：

click-chemistry; Huisgen's cycloaddition; triazole; antibiotic; MDR; S; aureus;

D O I：

10.1016/j.bmcl.2007.11.111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A small library of simple 1,4-disubstituted 1,2,3-triazoles was prepared using a known one-pot procedure starting from organic halides and terminal alkynes. The compounds were then tested for their antibacterial activity against normal and resistant species of Staphylococcus aureus. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1195 / 1198

页数：4

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