机构:
Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
Kings Coll London, MRC, London SE1 1UL, England
Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London SE1 1UL, EnglandKings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
Gould, Hannah J.
[1
,2
,3
]
Sutton, Brian J.
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机构:
Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
Kings Coll London, MRC, London SE1 1UL, England
Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London SE1 1UL, EnglandKings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
Sutton, Brian J.
[1
,2
,3
]
机构:
[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
[2] Kings Coll London, MRC, London SE1 1UL, England
[3] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London SE1 1UL, England
The spreading epidemic of allergies and asthma has heightened interest in IgE, the central player in the allergic response. The activity of IgE is associated with a network of proteins; prominent among these are its two principal receptors, FceRI (high-affinity Fc receptor for IgE) and CD23, as well as galectin-3 and several co-receptors for CD23, notably CD21 and various integrins. Here, we review recent progress in uncovering the structures of these proteins and their complexes, and in our understanding of how IgE exerts its effects and how its expression is regulated. The information that has emerged suggests new therapeutic directions for combating allergic disease.
机构:
Univ Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USAUniv Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USA
Rosenwasser, LJ
Meng, JF
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机构:Univ Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USA
机构:
Univ Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USAUniv Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USA
Rosenwasser, LJ
Meng, JF
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h-index: 0
机构:Univ Colorado, Div Allergy & Immunol, Dept Med,Hlth Sci Ctr, Natl Jewish Med & Res Ctr, Denver, CO 80202 USA