IgE in allergy and asthma today

被引:849
作者
Gould, Hannah J. [1 ,2 ,3 ]
Sutton, Brian J. [1 ,2 ,3 ]
机构
[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
[2] Kings Coll London, MRC, London SE1 1UL, England
[3] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London SE1 1UL, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/nri2273
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The spreading epidemic of allergies and asthma has heightened interest in IgE, the central player in the allergic response. The activity of IgE is associated with a network of proteins; prominent among these are its two principal receptors, FceRI (high-affinity Fc receptor for IgE) and CD23, as well as galectin-3 and several co-receptors for CD23, notably CD21 and various integrins. Here, we review recent progress in uncovering the structures of these proteins and their complexes, and in our understanding of how IgE exerts its effects and how its expression is regulated. The information that has emerged suggests new therapeutic directions for combating allergic disease.
引用
收藏
页码:205 / 217
页数:13
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