7,10-bis(2-mercapto-2-methyl)propyl-7,10-diazapalmitic acid: A novel, N2S2 ligand for technetium-99m

被引：14

作者：

Jones, GS ^{[1
]}

Elmaleh, DR ^{[1
]}

Strauss, HW ^{[1
]}

Fischman, AJ ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00440-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

7,10-Bis(2-mercapto-2-methyl)propyl-7,10 acid (7) was synthesized and evaluated as a new ligand for technetium-99m (Tc-99m). The title fatty acid analog, an achiral bis(aminoethanethiol) derivative in which the amines are tertiary, gave a stable complex with Tc-99m. The biodistribution of Tc-99m-labeled 7 in rats is reported. Copyright (C) 1996 Elsevier Science Ltd.

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页码：2399 / 2404

页数：6

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