Recent advances in the chemistry of 1,3-diketones: Structural modifications and synthetic applications

被引：104

作者：

Kel'in, AV ^{[1
]}

Maioli, A ^{[1
]}

机构：

[1] GLSynth Inc, Worcester, MA 01605 USA

来源：

CURRENT ORGANIC CHEMISTRY | 2003年 / 7卷 / 18期

关键词：

D O I：

10.2174/1385272033486134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Major aspects of the synthetic utility of 1,3-diketones are re viewed with special emphasis being placed on the regioselectivity of the transformations. The unsymmetrical 1,3-diketone moiety may contain up to five nucleophilic and two electrophilic centers that may only slightly differ in reactivity; therefore, it seems almost impossible to carry out chemical transformations with substrate selectively at only one specific center. However, in many cases it is possible, and in the present review answers to this question as well as many other useful synthetic applications of 1,3-diketones for the construction of carbocycles and heterocycles, and their modern implication in enantioselective, combinatorial, solid phase, and multistep organic syntheses are summarized.

引用

页码：1855 / 1886

页数：32

共 310 条

[31] Cerium catalyzed Michael addition of 1,3-dicarbonyl compounds under microwave irradiation [J].