Cu-Mediated Chemoselective Trifluoromethylation of Benzyl Bromides Using Shelf-Stable Electrophilic Trifluoromethylating Reagents

被引：109

作者：

Kawai, Hiroyuki ^{[1
]}

Furukawa, Tatsuya ^{[1
]}

Nomura, Yoshinori ^{[1
]}

Tokunaga, Etsuko ^{[1
]}

Shibata, Norio ^{[1
]}

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Frontier Mat, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 14期

关键词：

CATALYZED TRIFLUOROMETHYLATION; ENANTIOSELECTIVE TRIFLUOROMETHYLATION; ORGANIC HALIDES; NUCLEOPHILIC TRIFLUOROMETHYLATION; CONFIGURATIONAL STABILITY; REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; CONVENIENT METHOD; BORONIC ACIDS; SALT SYSTEM;

D O I：

10.1021/ol201205t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-mediated chemoselective trifluoromethylation at the benzylic :position by the use of shelf-stable electrophilic trifluoromethylating reagents 3 in good to high yields under mild conditions is described for the first time. The generality of this trifluoromethylation for a wide variety of benzyl bromides facilitates the rapid creation of structural diversity of medicinal candidates in drug discovery.

引用

页码：3596 / 3599

页数：4

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