BMP signaling and early embryonic patterning

被引：237

作者：

Kishigami, S ^{[1
]}

Mishina, Y ^{[1
]}

机构：

[1] NIEHS, Mol Dev Biol Sect, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC 27709 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 03期

关键词：

TGF-beta; BMP; receptor; embryogenesis; gastrulation; embryonic patterning;

D O I：

10.1016/j.cytogfr.2005.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) play pleiotropic roles during embryonic development as well as throughout life. Recent genetic approaches especially using the mouse gene knockout system revealed that BMP signaling is greatly involved in early embryonic patterning, which is a dynamic event to establish three-dimensional polarities. The purpose of this review is to describe the diverse function of BMPs through different receptor signaling systems during embryonic patterning including gastrulation and establishment of the left-right asymmetry. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：265 / 278

页数：14

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