Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

被引：54

作者：

Ho, H. P. ^{[1
]}

Yuan, W.

Wong, C. L.

Wu, S. Y.

Suen, Y. K.

Kong, S. K.

Lin, Chinlon

机构：

[1] Chinese Univ Hong Kong, Dept Elect Engn, Ctr Adv Res Photon, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China

来源：

OPTICS COMMUNICATIONS | 2007年 / 275卷 / 02期

关键词：

surface plasmon resonance; Fabry-Perot interferometry; biosensor; phase interrogation;

D O I：

10.1016/j.optcom.2007.03.067

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen.. and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：491 / 496

页数：6

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