Conjugated linoleic acid: Implications for human health

被引:212
作者
Whigham, LD
Cook, ME
Atkinson, RL [1 ]
机构
[1] Univ Wisconsin, Dept Med, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Nutrit Sci, Madison, WI USA
[3] Univ Wisconsin, Dept Anim Sci, Madison, WI USA
关键词
cancer; body composition; obesity; immune function; heart disease;
D O I
10.1006/phrs.2000.0735
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. This review will examine the literature on CLA and discuss the animal research on which the above claims are made. The limited human studies will be presented with an evaluation of the potential uses of CLA for human health and disease. (C) 2000 Academic Press.
引用
收藏
页码:503 / 510
页数:8
相关论文
共 77 条
[31]   Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice [J].
Hayek, MG ;
Han, SN ;
Wu, DY ;
Watkins, BA ;
Meydani, M ;
Dorsey, JL ;
Smith, DE ;
Meydani, SN .
JOURNAL OF NUTRITION, 1999, 129 (01) :32-38
[32]  
Horn WF, 1999, FASEB J, V13, pA226
[33]   Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat [J].
Houseknecht, KL ;
Vanden Heuvel, JP ;
Moya-Camarena, SY ;
Portocarrero, CP ;
Peck, LW ;
Nickel, KP ;
Belury, MA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 244 (03) :678-682
[34]   Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats [J].
Ip, C ;
Banni, S ;
Angioni, E ;
Carta, G ;
McGinley, J ;
Thompson, HJ ;
Barbano, D ;
Bauman, D .
JOURNAL OF NUTRITION, 1999, 129 (12) :2135-2142
[35]   Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis [J].
Ip, C ;
Scimeca, JA .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (02) :131-135
[36]   Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis [J].
Ip, C ;
Jiang, C ;
Thompson, HJ ;
Scimeca, JA .
CARCINOGENESIS, 1997, 18 (04) :755-759
[37]   EFFECT OF TIMING AND DURATION OF DIETARY CONJUGATED LINOLEIC-ACID ON MAMMARY-CANCER PREVENTION [J].
IP, C ;
SCIMECA, JA ;
THOMPSON, H .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1995, 24 (03) :241-247
[38]   The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet [J].
Ip, C ;
Briggs, SP ;
Haegele, AD ;
Thompson, HJ ;
Storkson, J ;
Scimeca, JA .
CARCINOGENESIS, 1996, 17 (05) :1045-1050
[39]  
IP C, 1991, CANCER RES, V51, P6118
[40]  
Jiang J, 1999, AM J CLIN NUTR, V70, P21