Amyloid beta-protein and lipid metabolism

被引：32

作者：

Zinser, Eva G. ^{[1
]}

Hartmann, Tobias ^{[1
]}

Grimm, Marcus O. W. ^{[1
]}

机构：

[1] Univ Saarland, Uniklinikum Homburg Neurobiol Neurol, D-66421 Homburg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2007年 / 1768卷 / 08期

关键词：

Alzheimer; amyloid; cholesterol; sphingolipid; raft; SREBP;

D O I：

10.1016/j.bbamem.2007.02.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipids play an important part as risk or protective factors for Alzheimer's disease. This review summarizes the current findings in which lipids influence Alzheimer's disease and introduces the molecular mechanism how these lipids are linked to amyloid production. Besides the pathological impact of amyloid in Alzheimer's disease, amyloid has a physiological function in regulating lipid homeostasis in return. The understanding of the resulting regulatory cycles between amyloid precursor protein processing and lipids provides a platform for the development of new causal therapeutic approaches for Alzheimer's disease. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：1991 / 2001

页数：11

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