Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin

被引：5

作者：

Daya, S ^{[1
]}

Walker, RB ^{[1
]}

Anoopkumar-Dukie, S ^{[1
]}

机构：

[1] Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa

来源：

METABOLIC BRAIN DISEASE | 2000年 / 15卷 / 03期

关键词：

cyanide; aspirin; free radical; neurotoxicity; lipid peroxidation; superoxide anion;

D O I：

10.1023/A:1011163725740

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuroprotective properties of aspirin were investigated using cyanide-induced neurotoxicity as model. Cyanide, a known neurotoxic agent significantly increased lipid peroxidation and superoxide anion levels in rat brain homogenate in a concentration-dependent manner (0.25-1.0 mM). When homogenate, containing 1.0 mM KCN was cotreated with aspirin (1.0 mM) there was a significant decrease in lipid peroxidation. Aspirin (0.5 mM and 1.0 mM) also significantly reduced KCN-induced superoxide anion generation. The results of the present report therefore indicate a neuroprotective role for aspirin.

引用

页码：203 / 210

页数：8

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