Efficacy of lamotrigine in refractory neonatal seizures

被引：11

作者：

Barr, PA

Buettiker, VE

Antony, JH

机构：

[1] Royal Alexandra Hosp Children, Dept Neonatol, Westmead, NSW, Australia

[2] Royal Alexandra Hosp Children, Dept Neurol, Westmead, NSW, Australia

来源：

PEDIATRIC NEUROLOGY | 1999年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0887-8994(98)00125-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A newborn infant with seizures of unknown etiology that were refractory to treatment with phenobarbitone, phenytoin, midazolam, clonazepam, and vigabatrin is reported. The introduction of the new antiepileptic drug lamotrigine was followed by rapid and sustained control of the seizures. (C) 1999 by Elsevier Science Inc. All rights reserved.

引用

收藏

页码：161 / 163

页数：3

相关论文

共 15 条

[1] CLONAZEPAM PHARMACOKINETICS AND THERAPEUTIC EFFICACY IN NEONATAL SEIZURES [J].

ANDRE, M ;

BOUTROY, MJ ;

DUBRUC, C ;

THENOT, JP ;

BIANCHETTI, G ;

SOLA, L ;

VERT, P ;

MORSELLI, PL .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 30 (05) :585-589

[2] LAMOTRIGINE FOR THE TREATMENT OF EPILEPSY IN CHILDHOOD [J].

BESAG, FMC ;

WALLACE, SJ ;

DULAC, O ;

ALVING, J ;

SPENCER, SC ;

HOSKING, G .

JOURNAL OF PEDIATRICS, 1995, 127 (06) :991-997

[3] THIOPENTAL EFFICACY IN PHENOBARBITAL-RESISTANT NEONATAL SEIZURES [J].

BONATI, M ;

MARRARO, G ;

CELARDO, A ;

PASSERINI, F ;

SCHIERONI, F ;

SPADA, P ;

VALSECCHI, R ;

DECAPITANI, E .

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1990, 15 (01) :16-20

[4] CELLULAR MECHANISMS OF EPILEPSY - A STATUS-REPORT [J].

DICHTER, MA ;

AYALA, GF .

SCIENCE, 1987, 237 (4811) :157-164

[5] VALPROIC ACID EFFICACY, TOXICITY, AND PHARMACOKINETICS IN NEONATES WITH INTRACTABLE SEIZURES [J].

GAL, P ;

OLES, KS ;

GILMAN, JT ;

WEAVER, R .

NEUROLOGY, 1988, 38 (03) :467-471

[6] LIDOCAINE FOR TREATMENT OF SEVERE SEIZURES IN NEWBORN-INFANTS .1. CLINICAL EFFECTS AND CEREBRAL ELECTRICAL-ACTIVITY MONITORING [J].

HELLSTROMWESTAS, L ;

WESTGREN, U ;

ROSEN, I ;

SVENNINGSEN, NW .

ACTA PAEDIATRICA SCANDINAVICA, 1988, 77 (01) :79-84

[7] INTRAVENOUS PARALDEHYDE FOR SEIZURE CONTROL IN NEWBORN-INFANTS [J].

KOREN, G ;

BUTT, W ;

RAJCHGOT, P ;

MAYER, J ;

WHYTE, H ;

PAPE, K ;

MACLEOD, SM .

NEUROLOGY, 1986, 36 (01) :108-111

[8] Neonatal seizures: A clinician's overview [J].

Lombroso, CT .

BRAIN & DEVELOPMENT, 1996, 18 (01) :1-28

[9] ANTIEPILEPTIC DRUG MECHANISMS OF ACTION [J].

MACDONALD, RL ;

KELLY, KM .

EPILEPSIA, 1995, 36 :S2-S12

[10] LORAZEPAM IN THE TREATMENT OF REFRACTORY NEONATAL SEIZURES [J].

MAYTAL, J ;

NOVAK, GP ;

KING, KC .

JOURNAL OF CHILD NEUROLOGY, 1991, 6 (04) :319-323