Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type

被引：161

作者：

Crozat, Karine ^{[1
,2
,3
]}

Tamoutounour, Samira ^{[1
,2
,3
]}

Thien-Phong Vu Manh ^{[1
,2
,3
]}

Fossum, Even ^{[4
,5
]}

Luche, Herve ^{[1
,2
,3
]}

Ardouin, Laurence ^{[1
,2
,3
]}

Guilliams, Martin ^{[1
,2
,3
]}

Azukizawa, Hiroaki ^{[6
]}

Bogen, Bjarne ^{[4
,5
]}

Malissen, Bernard ^{[1
,2
,3
]}

Henri, Sandrine ^{[1
,2
,3
]}

Dalod, Marc ^{[1
,2
,3
]}

机构：

[1] Univ Aix Marseille 2, Ctr Immunol Marseille Luminy, F-13288 Marseille 09, France

[2] INSERM, U631, F-13288 Marseille, France

[3] Ctr Natl Rech Sci, Unite Mixte Rech 6102, F-13288 Marseille, France

[4] Univ Oslo, Ctr Immune Regulat, Inst Immunol, N-0424 Oslo, Norway

[5] Oslo Univ Hosp, Rikshosp, N-0424 Oslo, Norway

[6] Osaka Univ, Course Integrated Med, Dept Dermatol, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2011年 / 187卷 / 09期

关键词：

ANTIGEN CROSS-PRESENTATION; SUBSET; RECEPTOR;

D O I：

10.4049/jimmunol.1101717

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression of CD11b and CD8 alpha in lymphoid tissues (LT), and of CD11b and CD103 in non-LT (NLT). Spleen CD8 alpha(+) and dermal CD103(+) DCs share a high efficiency for Ag cross-presentation and a developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived CD103(+) DCs and LT-resident CD8 alpha(+) DCs are similar despite their different anatomical locations. XCR1 was previously described as exclusively expressed on mouse spleen CD8 alpha(+) DCs and human blood BDCA3(+) DCs. In this article, we showed that LT-resident CD8 alpha(+) DCs and NLT-derived CD103(+) DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. Therefore, CD8 alpha(+) DCs and CD103(+) DCs belong to a common DC subset which is unequivocally identified by XCR1 expression throughout the body. The Journal of Immunology, 2011, 187: 4411-4415.

引用

页码：4411 / 4415

页数：5

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