Palladium-catalyzed couplings of heteroaryl amines with aryl halides using sodium phenolate as the stoichiometric base

被引：30

作者：

Schulte, James P., II ^{[1
]}

Tweedie, Scott R. ^{[1
]}

机构：

[1] Albany Mol Res Inc, Albany, NY 12203 USA

来源：

SYNLETT | 2007年 / 15期

关键词：

palladium-catalyzed; sodium phenolate; C-N bondforming; biaryl arnine; heteroaryl amine;

D O I：

10.1055/s-2007-985597

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heteroaryl amines are efficiently coupled (in two hours) to aryl halides with catalytic Pd(2()dba)(3) and Xantphos to provide the corresponding biaryl amines under microwave and standard thermal conditions. The use of organic-soluble sodium phenolate (NaOPh) as the stoichiometric base promotes facile coupling of a variety of substrates in excellent yields.

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收藏

页码：2331 / 2336

页数：6

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