Cardiovascular GO annotation initiative year 1 report: Why cardiovascular GO?

被引:13
作者
Lovering, Ruth C. [1 ]
Dimmer, Emily [2 ]
Khodiyar, Varsha K. [1 ]
Barrell, Daniel G. [2 ]
Scambler, Peter [3 ]
Hubank, Mike [4 ]
Apweiler, Rolf [2 ]
Talmud, Philippa J. [1 ]
机构
[1] UCL, Dept Med, Ctr Cardiovasc Genet, Rayne Inst, London WC1E 6JF, England
[2] European Bioinformat Inst, Cambridge, England
[3] Inst Child Hlth, Mol Med Unit, London, England
[4] Inst Child Hlth, Mol Hematol & Canc Biol Unit, London, England
关键词
clinical and basic research; Gene Ontology; heart and vascular disease;
D O I
10.1002/pmic.200800078
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Gene Ontology (GO) vocabularies are an established standard for linking functional information to genes and gene products (www.geneontology.org/). A recent collaboration between University College London and the European Bioinformatics Institute is providing GO annotation to human cardiovascular-associated genes (http://www.ucl.ac.uk/medicine/cardiovascular-genetics/ geneontology.html). This report outlines the aims of this collaboration and summarizes how the cardiovascular community can help improve the quality and quantity of GO annotations. This new initiative is funded by the British Heart Foundation and fully supported by the GO Consortium.
引用
收藏
页码:1950 / 1953
页数:4
相关论文
共 17 条
[1]   Gene Ontology: tool for the unification of biology [J].
Ashburner, M ;
Ball, CA ;
Blake, JA ;
Botstein, D ;
Butler, H ;
Cherry, JM ;
Davis, AP ;
Dolinski, K ;
Dwight, SS ;
Eppig, JT ;
Harris, MA ;
Hill, DP ;
Issel-Tarver, L ;
Kasarskis, A ;
Lewis, S ;
Matese, JC ;
Richardson, JE ;
Ringwald, M ;
Rubin, GM ;
Sherlock, G .
NATURE GENETICS, 2000, 25 (01) :25-29
[2]   Functional profiling of human atrial and ventricular gene expression [J].
Barth, AS ;
Merk, S ;
Arnoldi, E ;
Zwermann, L ;
Kloos, P ;
Gebauer, M ;
Steinmeyer, K ;
Bleich, M ;
Kääb, S ;
Pfeufer, A ;
Überfuhr, P ;
Dugas, M ;
Steinbeck, G ;
Nabauer, M .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2005, 450 (04) :201-208
[3]   The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology [J].
Camon, E ;
Magrane, M ;
Barrell, D ;
Lee, V ;
Dimmer, E ;
Maslen, J ;
Binns, D ;
Harte, N ;
Lopez, R ;
Apweiler, R .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D262-D266
[4]   The gene ontology annotation (GOA) project: Implementation of GO in SWISS-PROT, TrEMBL, and InterPro [J].
Camon, E ;
Magrane, M ;
Barrell, D ;
Binns, D ;
Fleischmann, W ;
Kersey, P ;
Mulder, N ;
Oinn, T ;
Maslen, J ;
Cox, A ;
Apweiler, R .
GENOME RESEARCH, 2003, 13 (04) :662-672
[5]   A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].
Frayling, Timothy M. ;
Timpson, Nicholas J. ;
Weedon, Michael N. ;
Zeggini, Eleftheria ;
Freathy, Rachel M. ;
Lindgren, Cecilia M. ;
Perry, John R. B. ;
Elliott, Katherine S. ;
Lango, Hana ;
Rayner, Nigel W. ;
Shields, Beverley ;
Harries, Lorna W. ;
Barrett, Jeffrey C. ;
Ellard, Sian ;
Groves, Christopher J. ;
Knight, Bridget ;
Patch, Ann-Marie ;
Ness, Andrew R. ;
Ebrahim, Shah ;
Lawlor, Debbie A. ;
Ring, Susan M. ;
Ben-Shlomo, Yoav ;
Jarvelin, Marjo-Riitta ;
Sovio, Ulla ;
Bennett, Amanda J. ;
Melzer, David ;
Ferrucci, Luigi ;
Loos, Ruth J. F. ;
Barroso, Ines ;
Wareham, Nicholas J. ;
Karpe, Fredrik ;
Owen, Katharine R. ;
Cardon, Lon R. ;
Walker, Mark ;
Hitman, Graham A. ;
Palmer, Colin N. A. ;
Doney, Alex S. F. ;
Morris, Andrew D. ;
Smith, George Davey ;
Hattersley, Andrew T. ;
McCarthy, Mark I. .
SCIENCE, 2007, 316 (5826) :889-894
[6]  
HARRIS MA, 2004, NUCL ACIDS RES, V32
[7]  
Harris MA, 2008, NUCLEIC ACIDS RES, V36, pD440, DOI 10.1093/nar/gkm883
[8]   A common variant on chromosome 9p21 affects the risk of myocardial infarction [J].
Helgadottir, Anna ;
Thorleifsson, Gudmar ;
Manolescu, Andrei ;
Gretarsdottir, Solveig ;
Blondal, Thorarinn ;
Jonasdottir, Aslaug ;
Jonasdottir, Adalbjorg ;
Sigurdsson, Asgeir ;
Baker, Adam ;
Palsson, Arnar ;
Masson, Gisli ;
Gudbjartsson, Daniel F. ;
Magnusson, Kristinn P. ;
Andersen, Karl ;
Levey, Allan I. ;
Backman, Valgerdur M. ;
Matthiasdottir, Sigurborg ;
Jonsdottir, Thorbjorg ;
Palsson, Stefan ;
Einarsdottir, Helga ;
Gunnarsdottir, Steinunn ;
Gylfason, Arnaldur ;
Vaccarino, Viola ;
Hooper, W. Craig ;
Reilly, Muredach P. ;
Granger, Christopher B. ;
Austin, Harland ;
Rader, Daniel J. ;
Shah, Svati H. ;
Quyyumi, Arshed A. ;
Gulcher, Jeffrey R. ;
Thorgeirsson, Gudmundur ;
Thorsteinsdottir, Unnur ;
Kong, Augustine ;
Stefansson, Kari .
SCIENCE, 2007, 316 (5830) :1491-1493
[9]   The mouse Gene Expression Database (GXD): updates and enhancements [J].
Hill, DP ;
Begley, DA ;
Finger, JH ;
Hayamizu, TF ;
McCright, IJ ;
Smith, CM ;
Beal, JS ;
Corbani, LE ;
Blake, JA ;
Eppig, JT ;
Kadin, JA ;
Richardson, JE ;
Ringwald, M .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D568-D571
[10]   Annotating the human proteome:: the Human Proteome Survey Database (HumanPSD™) and an in-depth target database for G protein-coupled receptors (GPCR-PD™) from Incyte Genomics [J].
Hodges, PE ;
Carrico, PM ;
Hogan, JD ;
O'Neill, KE ;
Owen, JJ ;
Mangan, M ;
Davis, BP ;
Brooks, JE ;
Garrels, JI .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :137-141