Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla

被引：121

作者：

Muraoka, O

Fujimoto, M

Tanabe, G

Kubo, M

Minematsu, T

Matsuda, H

Morikawa, T

Toguchida, I

Yoshikawa, M

机构：

[1] Kinki Univ, Sch Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

[2] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(01)00413-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Novel 14- norcadinane-type sesquiterpenes. oxyphyllenodiols A and B, and 11,12,13-trinoreudesmane-type sesquiterpenes. oxyphyllenones A and B, were isolated from the methanolic extract of kernels of Alpinia oxiphylla. The absolute stereostructures of these norsesquiterpenes were determined on the basis of physicochemical and chemical evidence. In addition, oxyphyllenodiol A and oxyphyllenone A were found to inhibit the NO production in lipopolysuccharide-activated macrophages. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2217 / 2220

页数：4

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