Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

被引：85

作者：

Peng, H

Moffett, J

Myers, J

Fang, XH

Stachowiak, EK

Maher, P

Kratz, E

Hines, J

Fluharty, SJ

Mizukoshi, E

Bloom, DC

Stachowiak, MK ^{[1
]}

机构：

[1] SUNY Buffalo, Mol & Struct Neurobiol & Gene Therapy Program, Buffalo, NY 14214 USA

[2] Arizona State Univ, Tempe, AZ 85287 USA

[3] Scripps Res Inst, La Jolla, CA 92037 USA

[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

来源：

MOLECULAR BIOLOGY OF THE CELL | 2001年 / 12卷 / 02期

关键词：

D O I：

10.1091/mbc.12.2.449

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type I and type 2 All receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

引用

页码：449 / 462

页数：14

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