The retromer protein VPS29 links cell polarity and organ initiation in plants

被引：201

作者：

Jaillais, Yvon ^{[1
]}

Santambrogio, Martina ^{[1
]}

Rozier, Frederique ^{[1
]}

Fobis-Loisy, Isabelle ^{[1
]}

Miege, Christine ^{[1
]}

Gaude, Thierry ^{[1
]}

机构：

[1] Univ Lyon 1, Ecole Normale Super Lyon, CNRS,Inst Natl Rech Agronom, Inst Federatif Rech 128,Reprod & Dev Plantes, 48 Allee Italie, F-69364 Lyon 07, France

来源：

CELL | 2007年 / 130卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.08.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A key feature of plants ( as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell by polarized auxin efflux carriers, termed PIN- FORMED ( PIN) proteins. Here we report that the Arabidopsis ortholog of the yeast and mammalian vacuolar protein sorting 29 ( VPS29), a member of the retromer complex, mediates the formation of new axes of development. Furthermore, we show that VPS29 is required for endosome homeostasis, PIN protein cycling, and dynamic PIN1 repolarization during development. We propose a model that links VPS29 function, PIN1 polarity, and organ initiation in plants.

引用

页码：1057 / 1070

页数：14

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