Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis

被引：61

作者：

Tzahor, Eldad ^{[1
]}

Evans, Sylvia M. ^{[2
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel

[2] Univ Calif San Diego, Skaggs Sch Pharm, La Jolla, CA 92093 USA

来源：

CARDIOVASCULAR RESEARCH | 2011年 / 91卷 / 02期

基金：

以色列科学基金会;

关键词：

Heart; Head muscle; Pharyngeal mesoderm; NEURAL CREST CELLS; CARDIAC OUTFLOW TRACT; MUSCLE DEVELOPMENT; ARTERIAL POLE; 2ND HEART; CIONA-INTESTINALIS; FIELD DEVELOPMENT; PROGENITOR CELLS; CARDIOVASCULAR PROGENITORS; CRANIOFACIAL MYOGENESIS;

D O I：

10.1093/cvr/cvr116

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The pharyngeal mesoderm (PM), located in the head region of the developing embryo, recently triggered renewed interest as the major source of cells contributing to broad regions of the heart as well as to the head musculature. What exactly is PM? In this review, we describe the anatomical and molecular characteristics of this mesodermal population and its relationship to the first and second heart fields in chick and mouse embryos. The regulatory network of transcription factors and signalling molecules that regulate PM development is also discussed. In addition, we summarize recent studies into the evolutionary origins of this tissue and its multipotential contributions to both cardiac and pharyngeal muscle progenitors.

引用

页码：196 / 202

页数：7

共 70 条

[1]

MyoD, modularity, and myogenesis:: conservation of regulators and redundancy in C-elegans [J].