Macrophage Polarization in Health and Disease

被引：240

作者：

Cassetta, Luca ^{[3
]}

Cassol, Edana ^{[4
]}

Poli, Guido ^{[1
,2
]}

机构：

[1] Ist Sci San Raffaele, AIDS Immunopathogenesis Unit, Div Immunol Transplantat & Infect Dis, Sch Med, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, Labs P2 P3, I-20132 Milan, Italy

[3] Albert Einstein Coll Med, Dept Dev & Mol Biol, Ctr Study Reprod Biol & Womens Hlth, Bronx, NY 10461 USA

[4] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

来源：

THESCIENTIFICWORLDJOURNAL | 2011年 / 11卷

关键词：

Macrophage; polarization; M1/M2; HIV; tumors; TAMs (tumor-associated macrophages); regulatory macrophages; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; NF-KAPPA-B; ALTERNATIVE ACTIVATION; MONOCYTE FUNCTION; SUPPRESSOR-CELLS; MAMMARY-TUMORS; STAPHYLOCOCCUS-AUREUS; HELMINTH INFECTION; MONONUCLEAR-CELLS;

D O I：

10.1100/2011/213962

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Macrophages are terminally differentiated cells of the mononuclear phagocyte system that also encompasses dendritic cells, circulating blood monocytes, and committed myeloid progenitor cells in the bone marrow. Both macrophages and their monocytic precursors can change their functional state in response to microenvironmental cues exhibiting a marked heterogeneity. However, there are still uncertainties regarding distinct expression patterns of surface markers that clearly define macrophage subsets, particularly in the case of human macrophages. In addition to their tissue distribution, macrophages can be functionally polarized into M1 (proinflammatory) and M2 (alternatively activated) as well as regulatory cells in response to both exogenous infections and solid tumors as well as by systems biology approaches.

引用

页码：2391 / 2402

页数：12

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