A bioactive self-assembled membrane to promote angiogenesis

被引：124

作者：

Chow, Lesley W. ^{[1
]}

Bitton, Ronit ^{[2
]}

Webber, Matthew J. ^{[3
]}

Carvajal, Daniel ^{[1
]}

Shull, Kenneth R. ^{[1
]}

Sharma, Arun K. ^{[2
,4
,5
]}

Stupp, Samuel I. ^{[1
,2
,6
,7
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Inst BioNanotechnol Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[4] Northwestern Univ, Sch Med, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA

[5] Childrens Mem Hosp, Div Pediat Urol, Chicago, IL 60614 USA

[6] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[7] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

来源：

BIOMATERIALS | 2011年 / 32卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Self-assembly; Angiogenesis; Heparin; Hyaluronic acid; Growth factors; Membrane; FIBROBLAST-GROWTH-FACTOR; PEPTIDE-AMPHIPHILE NANOFIBERS; IN-VITRO; HEPARIN; BIOLOGY; MINERALIZATION; BIOMATERIALS; REGENERATION; HYALURONAN; DELIVERY;

D O I：

10.1016/j.biomaterials.2010.10.048

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We report here on a bioactive hierarchically structured membrane formed by self-assembly. The membrane is formed with hyaluronic acid and peptide amphiphiles with binding affinity for heparin, and its hierarchical structure contains both an amorphous zone and a layer of fibrils oriented perpendicular to the membrane plane. The design of bioactivity is based on the potential ability to bind and slowly release heparin-binding growth factors. Human mesenchymal stem cells (hMSCs) seeded on these membranes attached and remained viable. Basic fibroblast growth factor (FGF2) and vascular endothelial growth factor (VEGF) were incorporated within the membrane structure prior to self-assembly and released into media over a prolonged period of time (14 days). Using the chicken chorioallantoic membrane (CAM) assay, we also found that these membranes induced a significant and rapid enhancement of angiogenesis relative to controls. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1574 / 1582

页数：9

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