First efficient synthesis of novel oxophenyl-arcyriaflavin analogs

被引：9

作者：

Bourderioux, A ^{[1
]}

Routier, S ^{[1
]}

Bénéteau, V ^{[1
]}

Mérour, JY ^{[1
]}

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 36期

关键词：

anticancer agents; indolocarbazoles synthesis; arcyriaflavin;

D O I：

10.1016/j.tetlet.2005.07.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New oxophenylarcyriaflavins were synthesized in a few efficient steps. The key steps involved at first a palladium cross-coupling between the 3-bromo-4-(1H-indol-3-yl)1-methyl pyrrole-2,5-dione and the 2-formylphenylboronic acid or a methyl 2-trialkylstannylbenzoate, followed by an intramolecular acylation in a C-2 indolic position. All the sequence was carried out without any indolic protective group. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6071 / 6074

页数：4

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