Ultra-fast synthesis of magnetic and luminescent silica beads for versatile bioanalytical applications

被引:29
作者
Müller-Schulte, D
Schmitz-Rode, T
Borm, P
机构
[1] MagnaMed GmbH, D-52066 Aachen, Germany
[2] Univ Hosp Aachen, Clin Radiol, Aachen, Germany
[3] Hogesch Zuyd Ctr Expertise Life Sci, NL-6400 Herrlen, Netherlands
关键词
silica; synthesis; DNA separation; encapsulation; quantum dots; photonic crystals; optical codes; inverse sol-gel suspension technique; silica hybrids;
D O I
10.1016/j.jmmm.2005.01.088
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
A method for the synthesis of both spherically shaped micro/nano silica particles and silica hybrid particles using a novel inverse sol-gel suspension technique was developed. The technique enables the synthesis of beads within seconds and provides a simple basis for quantum dot and biosubstances encapsulation. The carriers can be used as DNA adsorbents, individually addressable optical codes for bioassays and biomolecule library screening as well as photonic crystals. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:135 / 143
页数:9
相关论文
共 32 条
[1]   Preparation of spherical hydrous silica oxide particles under acidic condition via sol-gel processing [J].
Aizawa, M ;
Kitajima, S ;
Ohsawa, M ;
Yang, W .
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2000, 19 (1-3) :329-332
[2]   Semiconductor clusters, nanocrystals, and quantum dots [J].
Alivisatos, AP .
SCIENCE, 1996, 271 (5251) :933-937
[3]   Preparation and flow cytometry of uniform silica-fluorescent dye microspheres [J].
Bele, M ;
Siiman, O ;
Matijevic, E .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2002, 254 (02) :274-282
[4]   (CdSe)ZnS core-shell quantum dots: Synthesis and characterization of a size series of highly luminescent nanocrystallites [J].
Dabbousi, BO ;
RodriguezViejo, J ;
Mikulec, FV ;
Heine, JR ;
Mattoussi, H ;
Ober, R ;
Jensen, KF ;
Bawendi, MG .
JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (46) :9463-9475
[5]   Doping mesoporous materials with multicolor quantum dots [J].
Gao, XH ;
Nie, SM .
JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (42) :11575-11578
[6]   Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals [J].
Gill, I ;
Ballesteros, A .
TRENDS IN BIOTECHNOLOGY, 2000, 18 (07) :282-296
[7]   Multiplexed toxin analysis using four colors of quantum dot fluororeagents [J].
Goldman, ER ;
Clapp, AR ;
Anderson, GP ;
Uyeda, HT ;
Mauro, JM ;
Medintz, IL ;
Mattoussi, H .
ANALYTICAL CHEMISTRY, 2004, 76 (03) :684-688
[8]   Dye-labeled poly(organosiloxane) microgels with core-shell architecture [J].
Graf, C ;
Schärtl, W ;
Fischer, K ;
Hugenberg, N ;
Schmidt, M .
LANGMUIR, 1999, 15 (19) :6170-6180
[9]   Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules [J].
Han, MY ;
Gao, XH ;
Su, JZ ;
Nie, S .
NATURE BIOTECHNOLOGY, 2001, 19 (07) :631-635
[10]  
HERMANSON GT, 1996, BIOCONJUGATE TECHNIQ