The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

被引：151

作者：

Oberlies, NH ^{[1
]}

Croy, VL ^{[1
]}

Harrison, ML ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & MOL PHARMACOL,W LAFAYETTE,IN 47907

来源：

CANCER LETTERS | 1997年 / 115卷 / 01期

关键词：

acetogenins; bullatacin; multidrug resistance; P-gp; mammary adenocarcinoma;

D O I：

10.1016/S0304-3835(97)04716-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：73 / 79

页数：7

共 28 条

[1] MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN
AHAMMADSAHIB, KI
HOLLINGWORTH, RM
MCGOVREN, JP
HUI, YH
MCLAUGHLIN, JL
[J]. LIFE SCIENCES, 1993, 53 (14) : 1113 - 1120
[2] DESAI PB, 1995, CANCER CHEMOTH PHARM, V36, P368, DOI 10.1007/BF00686184
[3] ANNONACEOUS ACETOGENINS - AN UPDATED REVIEW
FANG, XP
RIESER, MJ
GU, ZM
ZHAO, GX
MCLAUGHLIN, JL
[J]. PHYTOCHEMICAL ANALYSIS, 1993, 4 (01) : 27 - 48
[4] Goldstein L J, 1995, Curr Probl Cancer, V19, P65
[5] BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER
GOTTESMAN, MM
PASTAN, I
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 : 385 - 427
[6] EXPLOITING MULTIDRUG-RESISTANCE TO TREAT CANCER
GOTTESMAN, MM
AMBUDKAR, SV
NI, B
ARAN, JM
SUGIMOTO, Y
CARDARELLI, CO
PASTAN, I
[J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 : 677 - 683
[7] GU ZM, 1995, RECENT ADV PHYTOCHEM, V29, P249
[8] Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide
Gupta, KP
Ward, NE
Gravitt, KR
Bergman, PJ
OBrian, CA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) : 2102 - 2111
[9] Bicinchoninic acid protein assay in the determination of adriamycin cytotoxicity modulated by the MDR glycoprotein
Hall, AM
Croy, V
Chan, T
Ruff, D
Kuczek, T
Chang, CJ
[J]. JOURNAL OF NATURAL PRODUCTS, 1996, 59 (01): : 35 - 40
[10] INABA M, 1988, CANCER RES, V48, P2064

← 1 2 3 →