Prospects for the Future Using Genomics and Proteomics in Clinical Microbiology

被引：40

作者：

Fournier, Pierre-Edouard ^{[1
]}

Raoult, Didier ^{[1
]}

机构：

[1] Univ Mediterranee, Unite Rech Malad Infect Trop & Emergentes, Fac Med, F-13385 Marseille 5, France

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 65 | 2011年 / 65卷

关键词：

genome sequence; proteome; diagnosis; culture; antibiotic susceptibility; vaccine; GLOBAL TRANSPOSON MUTAGENESIS; FRAGMENT LENGTH POLYMORPHISM; HAEMOPHILUS-INFLUENZAE RD; BACTERIAL VIRULENCE GENES; SMALL-MOLECULE INHIBITOR; IN-SILICO PREDICTIONS; GROUP-A STREPTOCOCCUS; GROUP-B STREPTOCOCCUS; RIBOSOMAL-RNA GENE; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1146/annurev-micro-090110-102922

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The availability of genome sequences has revolutionized the fields of microbiology and infectious diseases. Indeed, more than 1,000 bacterial genomes and 3,000 viral genomes, including representatives of all significant human pathogens, have been sequenced to date. Owing to this tremendous amount of data, genomes are regarded as chimeras of sequence fragments from various origins. Coupled with novel proteomic analyses, genome sequencing has also resulted in unprecedented advances in pathogen diagnosis and genotyping and in the detection of virulence and antibiotic resistance. Herein, we review current achievements of genomics and proteomics and discuss potential developments for clinical microbiology laboratories.

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页码：169 / +

页数：22

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