Heavy ion carcinogenesis and human space exploration

被引：442

作者：

Durante, Marco ^{[1
]}

Cucinotta, Francis A. ^{[2
]}

机构：

[1] Univ Naples Federico II, I-80126 Naples, Italy

[2] NASA, Lyndon B Johnson Space Ctr, Space Radiat Program, Houston, TX 77056 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期

基金：

美国国家航空航天局;

关键词：

D O I：

10.1038/nrc2391

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Before the human exploration of Mars or long-duration missions on the earth's moon, the risk of cancer and other diseases from space radiation must be accurately estimated and mitigated. space radiation, comprised of energetic protons and heavy nuclei, has been shown to produce distinct biological damage compared with radiation on earth, leading to large uncertainties in the projection of cancer and other health risks, and obscuring evaluation of the effectiveness of possible countermeasures. Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets.

引用

页码：465 / 472

页数：9

共 123 条

[1] GEANT4-a simulation toolkit [J].

Agostinelli, S ;

Allison, J ;

Amako, K ;

Apostolakis, J ;

Araujo, H ;

Arce, P ;

Asai, M ;

Axen, D ;

Banerjee, S ;

Barrand, G ;

Behner, F ;

Bellagamba, L ;

Boudreau, J ;

Broglia, L ;

Brunengo, A ;

Burkhardt, H ;

Chauvie, S ;

Chuma, J ;

Chytracek, R ;

Cooperman, G ;

Cosmo, G ;

Degtyarenko, P ;

Dell'Acqua, A ;

Depaola, G ;

Dietrich, D ;

Enami, R ;

Feliciello, A ;

Ferguson, C ;

Fesefeldt, H ;

Folger, G ;

Foppiano, F ;

Forti, A ;

Garelli, S ;

Giani, S ;

Giannitrapani, R ;

Gibin, D ;

Cadenas, JJG ;

González, I ;

Abril, GG ;

Greeniaus, G ;

Greiner, W ;

Grichine, V ;

Grossheim, A ;

Guatelli, S ;

Gumplinger, P ;

Hamatsu, R ;

Hashimoto, K ;

Hasui, H ;

Heikkinen, A ;

Howard, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303

[2] Mechanisms of therapy-related carcinogenesis [J].

Allan, JM ;

Lois, BT .

NATURE REVIEWS CANCER, 2005, 5 (12) :943-955

[3] TUMORIGENIC POTENTIAL OF HIGH-Z, HIGH-LET CHARGED-PARTICLE RADIATIONS [J].

ALPEN, EL ;

POWERSRISIUS, P ;

CURTIS, SB ;

DEGUZMAN, R .

RADIATION RESEARCH, 1993, 136 (03) :382-391

[4] Radiotherapy with beams of carbon ions [J].

Amaldi, U ;

Kraft, G .

REPORTS ON PROGRESS IN PHYSICS, 2005, 68 (08) :1861-1882

[5] Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor β-induced epithelial to mesenchymal transition [J].

Andarawewa, Kurnari L. ;

Erickson, Anna C. ;

Chou, William S. ;

Costes, Sylvain V. ;

Gascard, Philippe ;

Mott, Joni D. ;

Bissell, Mina J. ;

Barcellos-Hoff, Mary Helen .

CANCER RESEARCH, 2007, 67 (18) :8662-8670

[6] Tumor induction in mice locally irradiated with carbon ions: A retrospective analysis [J].

Ando, K ;

Koike, S ;

Oohira, C ;

Ogium, T ;

Yatagai, F .

JOURNAL OF RADIATION RESEARCH, 2005, 46 (02) :185-190

[7] Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers [J].

Baeyens, A ;

Thierens, H ;

Claes, K ;

Poppe, B ;

De Ridder, L ;

Vral, A .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2004, 80 (10) :745-756

[8] Radiation and the microenvironment - Tumorigenesis and therapy [J].

Barcellos-Hoff, MH ;

Park, C ;

Wright, EG .

NATURE REVIEWS CANCER, 2005, 5 (11) :867-875

[9] TGFβ:: the molecular Jekyll and Hyde of cancer [J].

Bierie, Brian ;

Moses, Harold L. .

NATURE REVIEWS CANCER, 2006, 6 (07) :506-520

[10] Diet and cancer - The European prospective investigation into cancer and nutrition [J].

Bingham, S ;

Riboli, E .

NATURE REVIEWS CANCER, 2004, 4 (03) :206-215

← 1 2 3 4 5 6 7 8 9 10 →